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SNRI Drugs: Depression Medication


SNRI drugs (along with SSRI’s) are amongst the most commonly prescribed antidepressants in the treatment for depression. This may be due to them having less adverse side effects compared to other types of antidepressants (such as; TCAs).[1Opens in a new tab.]

SNRI stands for Serotonin-Norepinephrine Re-uptake Inhibitor.

They are given this name because they are said to “inhibit the re-uptake” of both neurotransmitters (messenger molecules); Serotonin + Norepinephrine, into the pre-synaptic neurons.

So, what does that mean in plain english?!

Well, this act of inhibiting the natural recycling process of Serotonin + Norepinephrine is said to increase the availability of the neurotransmitters (messenger molecules) within the brain, which is believed to alleviate the ‘symptoms’ of depression.

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  • Want to see the basic process of how SNRI’s are said to work to treat depression and how they inhibit the “re-uptake” of Serotonin + Norepinephrine?  Then, be sure to watch: How Do Antidepressants Work?

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SNRI Drugs List

Here’s a list of some commonly prescribed SNRI drugs.

  • DesvenlafaxineOpens in a new tab. – Pristiq – Zyven-OD – Khedezla
  • DuloxetineOpens in a new tab. – Cymbalta – Duciltia – Ariclaim – Yentreve – Depalta – Yelate – Xeristar – Dulane – Duzela
  • LevomilnacipranOpens in a new tab. – Fetzima
  • MilnacipranOpens in a new tab. – Ixel – Savella – Dalcipran – Toledomin – Joncia
  • VenlafaxineOpens in a new tab. – Effexor – Elafax – Enlafax – Sunveniz – Venlalic – Depefex – Alventa – Venaxx – Venzip – Conervin Retard – Elify XR – ViePax – Ixilania – Venladex – Dalium – Odiven – Politid – Sentosa

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Most Common Side Effects of SNRI’s

SNRI’s may cause:

  • Nausea / vomiting
  • Feeling agitated, shaky or anxious
  • Indigestion
  • Diarrhoea or constipation
  • Dizziness / Lightheadedness
  • Confusion
  • Blurred vision
  • Increased risk of suicidal thinking &/or suicidal behaviour
  • Dry mouth
  • Weight loss
  • Weight gain
  • Excessive sweating
  • Sexual dysfunction
  • Abnormal ejaculation
  • Difficulty passing urine
  • Drowsiness
  • Restlessness
  • Lack of energy / fatigue
  • Decreased libido
  • Nervousness
  • Sleeping disturbance (insomnia)
  • Abnormal dreams or vision
  • Headaches
  • Cognitive &/or memory impairment
  • Lack of interest, enthusiasm or concern
  • Inability to feel pleasure in normally pleasurable activities
  • Emotional blunting
  • Bruising or bleeding easily
  • Movement troubles, such as; stiffness or shaking
  • Myalgia (muscle pain)
  • Abnormal physical weakness
  • Akathisia
  • Low blood pressure
  • Tremors or muscle twitches
  • Abdominal pain
  • Skin reactions / rashes
  • Hyponatremia (low sodium blood levels)
  • Cold / flu-like symptoms
  • Sinus, nose or upper respiratory infections
  • Manic switch (switching of mood into mania)
  • Increased risk of gastrointestinal (stomach/intestinal) bleeding
  • Increased risk of Serotonin Syndrome

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Antidepressant Warnings

Antidepressant drugs can interact with other medications, foods and natural supplements (for example; St Johns Wort) which may increase the risk of Serotonin Syndrome, so be sure to speak to your doctor or healthcare provider to ensure there’s no negative interactions.


If you would like to personally assess how your medications may interact with each other, then simply click here to use the FREE Drug Interactions CheckerOpens in a new tab.. This will inform you of any possible negative interactions of your medications.

NOTE: Always consult your healthcare provider to ensure the information displayed on the Drug Interactions page applies to your personal circumstances. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

WARNING:  *** NEVER stop an antidepressant drug without first consulting your healthcare provider. Suddenly stopping an antidepressant drug can cause adverse effects.***

NOTE:  The content on this page is for general information purposes only.  This page is not intended to give advice regarding SNRI Antidepressants (SNRIs).


IMAGE CREDIT: Photo by Thought CatalogOpens in a new tab.

Marie O'Neil

As an Overcoming Depression Specialist, I get so frustrated with all the 'mental illness myths' and half-truths keeping people stuck in the downward spiral of depression. It doesn’t need to be that way! THERE IS A WAY OUT! If I can do it, so can you! You just need the right, time-tested tools and proven strategies to help you do it. And, that's what this website is all about. Giving you light in the darkest of times. To learn more about me simply click here.

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